Request pdf reporting and grading of abnormal red blood cell morphology in spite of the continual standardization of test result formats, the. Hereditary stomatocytosis hst is a rare disorder that presents with various degrees of hemolytic anemia and abnormal red blood cell rbc morphology. The marked rbc microcytosis and hypochromia are evident. Rbc morphology and disease that may be associated with. Rbc morphology and disease that may be associated with abnormal morphologies. The presence of certain types of pathologic erythrocytes in the peripheral. Others may be due abnormalities such as iron deficiency. Normal rbcs are biconcave in shape with a central pale area, and any deviation in size, shape, volume, structure or color represents an abnormal cell. Some of these changes can be pathologic in one context or in one species or physiologic in another. Jan 23, 2017 abnormal rbc morphology can mean changes in size of the rbc. What is rbc morphology and what does it mean when your. The description of red blood cells extends back to the earliest days of the development of the microscope. Secondly, is the morphology pathologic and not artificially induced. No one here can tell you what this means though it is of course very concerning.
Im a medical technologist and i am also a science graduate. My understanding is that reactive lymphs are lymphocytes that are enlarged due to some stimulus. Nucleated erythrocytes are not identified according to stage of maturation, but the total number present on a differential cell count should be reported. Red cell morphology in leukemia, hypoplastic anemia and myelodysplastic syndrome. Rbc morphology in a normal individual rbcs show minimal anisocytosis and poikilocytosis. Summary of abnormal red blood cell morphologies and. Summary of abnormal red blood cell morphologies and disease. Especially with the abnormal morphology of the lymphocytes, you need to speak either with the treating physician primary care or consulting hematologist or with a physician you trust.
The page below is a sample from the labce course red cell disorders. For example, small heinz bodies are commonly seen in the blood of cats without causing anemia. The most significant of these is the reticulocyte, the immediate precursor to the red blood cell. This examination was qualitative rbc morphology, sediment casts and urine chemistry and quantitative cell count per 10 high power field, mg. A great resource for practicing rbc morphology evaluation. Morphology based detection of abnormal red blood cells in. Appears to be of the same size as the nucleus of the small lymphocyte. Larger than average rbcs are macrocytic left, while those smaller than average are microcytic right. Infectious organisms may cause hemolytic anemia through the direct action of toxins eg, from clostridium perfringens, alpha or betahemolytic streptococci, meningococci, by invasion and destruction of the rbc by the organism eg, plasmodium species, bartonella species, or by antibody production eg, epsteinbarr virus, mycoplasma. Red cell morphology in leukemia, hypoplastic anemia and myelodysplastic syndrome article in pathophysiology 4. Jul 22, 2014 rbc morphology and disease that may be associated with abnormal morphologies. Some of these may be due to a primary blood disorder such as sickle cell anemia.
The medical college of virginias discussion of abnormal rbc morphology includes a number of different types of anemia, a term which the mayo clinic describes as a decreased number of red blood cells. Reporting and grading of abnormal red blood cell morphology. Red cell morphology in leukemia, hypoplastic anemia and. The key word for it is biconcave disc, meaning that it is a disc shaped or circular cell that is compressed at the centre in both directions.
Red blood cell morphology, grading system, standardization summary in spite of the continual standardization of test result formats, the improvements of laboratory technologies, publications of reference guidelines, and the advancements in hematology analyzers, the methods of reporting or grading abnormal red blood cell morphol. In cases of hpa, there was loss of the biconcave shape of red cells with thinner andor translucent appearance shown in fig. Hereditary stomatocytosis hst is an inherited autosomal dominant condition characterized by an excess of stomatocytes patients have variable degrees of hemolysis and anemia. Specimen whole blood from one full lavendertop edta tube or wrightsstained, thinfilm peripheral blood smear. Rbc morphology 10 questions by lvanvalkenburg last updated. The most common terms include 1 normocyticcells are of normal size. It can be caused by various anemias, such as iron deficiency where the cells will be smaller than normal pernicious anemia, where cells are larger than normal b12 deficiency. The red blood cell morphology case simulator is the perfect tool to hone the skills of everyone interested in blood smear morphology. The are numerous abnormalities that can occur in different types of illness.
There are hints as to the morphology within the blood count. Home hematology abnormal red blood cells morphology and possible causes abnormal red blood cells morphology and possible causes. A redesign of rbc morphology reporting article pdf available in mlo. Red blood cells morphology and disease that may be associated with abnormal morphologiesfaheem javed bsc, microscopist 2. Complete blood count, rbc morphology and inclusions. Albumin anemia artifact ascaris lumbricoides bacteria basophil basophilic stippling bilirubin blood agar blood smear candida candida albicans cbc chocolate agar cml e. Red blood cell morphology, anemia, peripheral blood. In patients with microcytic anemia, rbc morphology can increase or decrease the diagnostic likelihood of thalassemia. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Rbc morphology with microcytic rbc download here free healthcaremagic app to ask a doctor all the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. Each species has its own characteristics, in fact you would expect to see a rouleaux condition on.
Subject lab 1 slide preparation and staining, the white blood cell differential, and platelet estimation. In 1658 swammerdam described the oval red blood cells of the frog, and in 1673 leeuwenhoek discovered the red cells in human blood and described them as circular in contrast to amphibian cells. Free laboratory science flashcards about rbc morphology. The normal red blood cell to identify abnormal morphology, one must be competent in normal morphology identi. It is limited to the material covered in the lectures and laboratory sessions. Rbc morphology a hypo doctor answers on healthcaremagic. Firstly, is the abnormal morphology seen in every field to be examined. Abnormal morphology of blood cells april 2012 hematologyimmunology system faculty of medicine universitas padjadjaran. Rbc morphology reporting per high power field 400x few.
Normal red cell fragile, biconcave, disk like structure. Tem studies revealed presence of pores with diameters ranging from 100 to 200nm on the rbc membrane surface of myeloid leukemia with aml being the most prominent among others. Guidelines for reporting red blood cell morphology labce. Rbc morphology is recorded using the four classic descriptors listed below, i. Rbc morphology is when they look at the red blood cells under the microscope. Red blood cell storage and cell morphology 93 storage 42 days, haemolysis was lower than the 0 8% threshold for all the tested subjects 0 34 0 1 fig. Morphology is to do with the size, shape, colour etc of the cell. How to interpret and pursue an abnormal complete blood cell. Complete blood count, rbc morphology and inclusions synonymacronym. Jun 16, 2010 under rbc morphology the results were. For all the acute leukemia cases blast counts ranged from 50 to 85% and for all chronic leukemia blast counts were. Peripheral blood clues to nonneoplastic conditions. Pdf this paper focused obtaining new features for improved classification of red. These include assessment of rbc shape, size, color, inclusions, and arrangement.
American proficiency institute 2014 2nd test event cell. Normal mature rbc are biconcave, round discs that are about 6 8 in diameter, which is only slightly smaller than the normal small mature lymphocytes about 6 10 in diameter. Have no nucleus whole cell is filled with the haemoglobin. In health, the red blood cells vary relatively little in size and shape. Your doctor can use rbc indices to help diagnose the cause of anemia. Morphological abnormalities of red blood cells the art of. Abnormal red blood cells morphology and possible causes. Overview of hemolytic anemia hematology and oncology. Such pathophysiological alterations of the rbc morphology in leukemic patients could be identified as characteristic signature of the onset of anemia associated with the disease. Quantification of red blood cell morphology springerlink. Peripheral smear from a child with hemoglobin of 7. The red colour of red cells is due to the presence or haemoglobin rbcs survive for. The presentation of illustrative cells in this module is by no means a comprehensive study of blood cells. This includes medical laboratory science students, medical students, experienced medical laboratory professionals, resident physicians, hematologists, and pathologists.
Rbc morphology veterinary technology dvt10 with mrs. Free flashcards to help memorize facts about hematology1 test on rbc morphology deltech owens. Polychromasia is a medical condition in which there is an abnormally high amount of immature red blood cells being released into the bloodstream. Pdf new normal and abnormal red blood cells features for. Scanning electron microscopic observations revealed changes in the overall morphology of the red cells isolated from the leukemic patients and changes seemed to vary with the type of hematological malignancy.
Rare poikilocytosis poikilocytosis is a general term for abnormally shaped red blood cells. Clearly we can all appreciate the normal shape of a red blood cell. Rbcs abnormal morphology free download as powerpoint presentation. In wellspread, dried and stained films the great majority of cells have round, smooth contours and diameters within the comparatively narrow range of 6. The rbc indices measure the size, shape, and physical characteristics of the rbcs. Abnormal rbc morphology can mean changes in size of the rbc. Blood cell morphology in health and disease clinical gate. Platelet morphology is normal in rt, but the pbs may reveal the presence of. Complete cases of common blood disorders peripheral blood, bone marrow, and diagnostic studies. The only difference between the reticulocyte and the red blood cell is the presence of a meshwork. Hemoglobin can be high or low meaning that blood cells are darker or lighter in colour than. Abnormal red blood cell morphology answers on healthtap. Such pathophysiological alterations of the rbc morphology in leukemic patients could be identified as characteristic signature of the onset of anemia associated with the. Rbc morphology is the appearance of the red cells under the microscope.
Tutorial blood cell morphology a clinical pathology 201. Morphological abnormalities of red blood cells the art. Rbc morphology changes due to metabolicmembrane do environmental exposure, both in vitro and in vivo can result in loss of normal discoid shape to some other variation. Abnormalities of rbc shape and other rbc features can provide key information in establishing a differential diagnosis. Tutorial blood cell morphology louisiana state university health sciences center department of pathology new orleans, louisiana. Unfortunately, a few cell illustrations are not available at this time but will be added later. Majumder d1, banerjee d, chandra s, banerjee s, chakrabarti a. The red colour of red cells is due to the presence or. A semiquantitative estimate method for reporting abnormal rbc. Common use to make a visual evaluation of the red cell shape andor size as a confirmation in assisting to diagnose and monitor disease progression. Study 75 pictures of rbc morphology flashcards from meagan b. Visual description of rbc morphology on a romanowsky stain also provides useful diagnostic information. There are also changes that occur in red blood cells that can give us clues as to underlying diseases. Abnormal morphology of red blood cell when a blood smear is inspected for abnormal morphology, two criteria must be met.
List the terms referring to abnormal red cell distribution, variation in red cell size. What are the abnormal red blood cells that are indicated by the arrows in this. Before we start with the abnormal morphologies, lets talk about normal morphology of red blood cells. Identify normal red blood cell morphology on a peripheral smear. The child had received an rbc transfusion prior to smear being performed accounting for the dual population of rbcs. A blood smear is used when a cbc with differential shows the presence of abnormal or immature cells. One of the more common of these is sickle cell anemia, a disease in which hemoglobin, a protein found in red blood cells, is abnormal and causes. The labce red blood cell morphology case simulator, produced in collaboration with the louisiana state university health science center, includes 25 welldocumented case studies from patients with a variety of conditions affecting rbc morphology. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests. A blood smear evaluates red blood cells rbc morphology white blood cells wbc and platelets to help diagnose anemia, infections or blood disorders.
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